Key genetic variants in the renin-angiotensin system and left ventricular mass in a cohort of Polish patients with heart failure

Background: Heart failure (HF) is a complex disease that under the control of different physiological systems. Left ventricular mass (LVM) strong predictor HF. The renin-angiotensin system (RAS) may contribute to pathogenesis HF and LVM. Aims: aim this study examine association between RAS genetic variants LVM in cohort Polish patients with Methods: included 401 Two-dimensional M-mode echocardiography was used assess Genomic DNA extracted from blood, genotyping angiotensin-converting enzyme (ACE) (rs4646994), angiotensinogen (AGT) (rs5051), angiotensin II receptor type 1 (AGTR1) (rs5186) polymorphisms carried out using polymerase chain reaction (PCR). Results: A significant found genotypes G(–6)A AGT, homozygotes AA AGT were significantly less common vs group. results did not confirm relationship ACE AT1R Conclusions: Our suggested polymorphism play protective role development